CSIR Life Science Question Paper with Answers June And December 2016

A shopkeeper purchases a product for Rs.100 and sells it making a profit of 10%. The customer resells it to the same shopkeeper incurring a loss of 10%. In these dealings the shopkeeper makes

A person walks downhill at 10 km/h, uphill at 6 km/h and on the plane at 7.5 km/h. If the person takes 3 hours to go from a place A to another place B, and 1 hour on the way back, the distance between A and B is

At one instant, the hour hand and the minute hand of a clock are one over the other in between the markings for 5 and 6 on the dial. At this instant, the tip of the minute hand

A cubical cardboard box made of 1 cm thick card board has outer side of 29 cm. A tight-fitting cubical box of the same thickness is placed inside it, then another one inside it and so on. How many cubical boxes will be there in the entire set?

Statement A. The following statement is true Statement B. The preceding statement is false.

Choose the correct inference from the following:

A car is moving at 60km/h. The instantaneous velocity of the upper most points of its wheels is

If D + I + M = 1501

             C + I + V + I + L = 157

             L + I + V + I + D = 557

             C + I + V + I + C = 207

What is V + I + M = ?

Density of a rice grain is 1.5 g/cc and bulk density of rice heap is 0.80 g/cc. If a 1 litre container is completely filled with rice, what will be the approximate volume of pore space in the container?

A turtle starts swimming from a point A located on the circumference of a circular pond. After swimming for 4 meters in a straight line it hits point B on the circum-ference of the pond. From there it changes direction and swims for 3 meters in a straight line and arrives at point D diametrically opposite to point A. How far is point D from A?

A film projector and microscope give equal magnification. But a film projector is not used to see living cells because

Enzymes accelerate a reaction by which one of the following strategies?

Coupling of the reaction centers of oxidative phosphorylation is achieved by which one of the following?

Glycophorin having one highly hydrophobic domain is able to span a phospholipid bilayer membrane only

Which one of the following chemicals is a DNA intercalator?

An antibiotic that resembles the 3’end of a charged tRNA molecule is:

Cytotoxic T cells express

The mutation in an oncogene falls under which of the following classes?

Which of the following is NOT a cell adhesion protein?

Which of the following is NOT a second messenger?

In chick, development of wing feather, thigh feather and claws depends on epithelial specificity conferred by induction from mesenchymal components from different sources of the dermins. This may be attributed to?

Alveolar cells of the lung arise from which one of the following layer(s)?

Migration of individual cells from the surface into the embryo’s interior is termed as

Floral organ development is controlled by overlapping expression of ‘A’ class, ‘B’ class and ‘C’ class genes in different whorls. In an Arabidopsis mutant, the flowers had sepals, sepals, carpels and carpels in the four whorls. Mutation in which one of the following is the cause for the mutant phenotype?

Phenylalanine, a precursor of most of the phenolics in higher plants is a product of which one of the following pathways?

A diabetic patient developed metabolic acidosis resulting in deep and rapid breathing which is called-

Which one of the following is NOT involved with the pacemaker potential of heart?

You are asked to identify the stage of estrus cycle in vaginal smear of a mouse containing large number of leukocytes and very few nucleated epithelial cells. Which one of the following will be the correct stage of estrous cycle?

Which one of the following neurotransmitters is secreted by the pre-ganglionic neurons of sympathetic nervous system?

Mutation in gene ‘X’ leads to lethality in a haploid organism. Which one of the following is best suited to analyse the function of gene ‘X’?

In a heterozygous individual for a given gene, if a crossing over has occurred between the gene locus and the centromere of the chromosome, the segregation of the two alleles of the given gene will occur during meiosis at

Most members of bryophyte phylum Anthocerophyta are characterized by

Identify the correct match between the animal (flatworm, earthworm, roundworm) and its body cavity type (acoelomate, coelomate, pseudo- coelomate):

Which one of the following gymnosperm phyla produces motile sperms, bears ovulate and microsporangiate cones on separate plants and has fleshy, coated seeds?

According to 2014 IUCN Red List, which of the following vertebrate classes has the largest percentage of threatened species?

Which gas does NOT contribute to global warming through its greenhouse effect?

A red coloured tubular flower without any odour is most likely to be pollinated by

Which one of the following conditions is NOT likely to favour male monogamy?

The origin and diversification of Angio- sperms was during which geological period?

Which of the following statements about evolution is NOT true?

Which among the following is the simplest method to estimate the concentration of glycerol in an aqueous solution of glycerol?

Application of gene therapy in clinical trials did NOT succeed due to

A gene expressing a 50 kDa protein from an eukaryote was cloned in an E. coli plasmid under the lac promoter and operator. Upon addition of IPTG, the 50 kDa protein was not detected. Which one of the following explains the above observation?

Neomycin phosphortransferase gene, frequently used as a selection marker during plant transformation, inactivates which one of the following antibiotics?

Which one of the following techniques will you use to identify more than 1000 differentially expressed genes in normal and tumor tissues in one single experiment?

For identification of three proteins moving together (as a single band) upon loading in a single lane of a SDS-PAGE gel, the best method is:

Which one of the following would contribute to intrinsic fluorescence to a protein?

A culture medium contains two carbon sources, one is preferred carbon source (glucose) and the second is a non-preferred source (lactose).

Which one below is correct regarding the nature of growth curve of E. coli cultured in this medium?

Which one of the following statements correctly applies to proteins which are translated on the rough endoplasmic reticulum?

Lipid rafts are rich in both sphingolipids and cholesterol. Cholesterol plays a central role in raft formation since lipid rafts apparently do not form in its absence. Why do you think cholesterol is essential for the formation of lipid rafts?

The frequency of cells in a population that are undergoing mitosis (the mitotic index) is a convenient way to estimate the length of the cell cycle. In order to measure the cell cycle in the liver of the adult mouse by measuring the mitotic index, liver slices are prepared and stained to easily identify cells undergoing mitosis. It was observed that only 3 out of 25,000 cells are found to be undergoing mitosis. Assuming that M phase lasts 30 minutes, calculate the approximate length of the cell cycle in the liver of an adult mouse?

The mismatch repair activity of E.coli repairs misincorporated bases which is not removed by the proofreading activity of DNA polymerase. However, while doing so, it has to decide which strand of the DNA is newly synthesized and which one is parental. Mismatch repair system does it by which one of the following ways?

Instructive and permissive interactions are two major modes of inductive interaction during development. The following compares some properties of cell lines and cord blood stem cells. Cell lines, which are stored in liquid nitrogen, can be retrieved for experiments, where they behave as per their original self. Cord blood can also be retrieved from liquid nitrogen for procuring stem cells. Unlike cell lines, the stem cells can be additionally induced to undergo differentiation into desired lineages, which are very different from their original self. The behaviour of cell lines and stem cells is analogous to which of the interactions?

Successful fertilization in sea urchin demands specific interaction between proteins and receptors of sperms and eggs. In view of the above, which one of the following combinations is correct?

The afferent nerve fibres of a stretch reflex were electrically stimulated and the contraction of the muscle innervated by efferent fibres was recorded. The synaptic delay was calculated from the time points of the nerve stimulation and response of the muscle. Which one of the following time durations will be probable value for the observed synaptic delay?

Two siblings who inherit 50% of the genome from the mother and 50% from the father show lot of phenotypic differences. Which one of the following events during gametogenesis of the parents will maximally contribute to this difference?

Of the following, which one of the individuals will NOT necessarily carry the allele responsible for the mentioned trait?

A population is growing logistically with a growth rate (r) of 0.15/week, in an environment with a carrying capacity of 400. What is the maximum growth rate (No. of individuals/week) that this population can achieve?

Individual A can derive ‘fitness’ benefit of 160 units by helping Individual B, but incurs a ‘fitness’ cost of 50 units in doing so. Following Hamilton’s Rule, A should help B ONLY if B is his

The “Red Queen Hypothesis” is related to

As cancer progresses, several genome rearrangements including translocation, deletion, duplications etc. occur. If these rearrangements are to be identified, which of the following techniques would be most suitable?

A researcher is studying the subcellular localization of a particular protein ‘X’ in an animal cell. The researcher performs successive centrifugation at increasing rotor speed. The researcher starts spinning the cellular homogenate at 600g for 10 min, collects the pellet, spins the supernatant at 10,000 g for 20 min, collects the pellet, spins the supernatant at 100,000g for 1 hour, collects both the pellet and the final supernatant. On subjecting various pellets and the final supernatant to Western blotting with anti-protein-X antibody, the protein X is observed to be maximally expressed in pellet after centrifugation at 10,000 g. Based on the above observation, what will be the most likely localization of protein X.

Fluorescence recovery after photobleaching in live cells is used to determine

During an experiment, a student found increased activity of a protein, for which there were three possible explanations, viz., increased expression of the protein, increased phosphorylation, or increased interaction with other effector proteins. After conducting several experiments, the student concluded that increased activity was due to increased phosphorylation. Which one of the following experiments will NOT support/provide the correct explanation drawn by the student?